Figure 4. The power of the MON to conduct CAPs is determined by the balance between tissue and energy demand and provide of substrate to the nerve. In MONs equipped with 10 mM glucose the imposition of one hundred Hz stimulus causes the CAP space to fall. However replacing 10 mM glucose with 30 mM glucose within the aCSF restores the CAP to its full space. The horizontal bars indicate the glucose concentration present in the aCSF. The position that lactate plays in the above results was investigated. Clausen, 1992). The usage of the compound cinnemate, which blocks lactate uptake into axons, was strategically used to dissect the element of lactate use. CIN, as well as D-lactate, have to be used appropriately since they not only block membrane floor transporters but additionally block pyruvate uptake into mitochondria. In the presence of two mM glucose addition of 150 μM CIN induced a speedy CAP decrease, indicative of glycogen-derived lactate appearing as a supplemental substrate in the presence of two mM glucose (Brown et al., 2003). However in the presence of 10 mM glucose CIN had no impact (Brown et al., 2003). This management experiment has far reaching penalties, because it means that not all glucose is shuttled via astrocytes, but that axons can instantly take up glucose.
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