"Our work challenges the textbook mannequin of how the mind fuels itself. Neurons are extra self-adequate than we thought," Singh stated. Co-author Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, stated the research helps the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer rapid shifts in vitality demand," Colón-Ramos stated. Other authors, all from Yale, embrace Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate student in cell biology; Anjali A. Vishwanath and Anastasia Tsives, put up-doctoral researchers in neuroscience; and Richard Goodman, a research scientist in neuroscience. Original Research: Open access. "Glycogen supports glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the biggest power reserve in the brain, but the specific function of glycogen in supporting neuronal vitality metabolism in vivo isn't nicely understood. We carried out an RNAi display screen and recognized that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We determined that neurons make use of at the least two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-impartial glycolytic plasticity. We uncover that GDGP is employed underneath circumstances of mitochondrial dysfunction, such as transient hypoxia or in mutants for mitochondrial perform.
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